… Furthermore, 378 general limitation eg the mechanical properties of the utilized artificial
models compared to 379 that of inner ear tissue might confine the transferability of the results …

… properties of EVs specific to inner ear delivery. This review will … genetic materials targeting
inner ear cells or tissues, could … of MSC-EVs on hearing in a noise trauma mouse model. Their …

… management into the pathologies of the inner ear using drug delivery system, also to review
… Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse. …

… 1 mouse model of dominant progressive hearing loss, we demonstrated the effective delivery
of RNP-EVs into inner ear … in the inner ear tissue for accessing and targeting inner ear cells …

… option for inner ear gene delivery in a … in mouse models of hearing loss, larger animal
model studies are needed to ensure the efficacy of these approaches. In summary, gene delivery …

… the pharmacokinetic and pharmacodynamic properties in vivo… m Treatment protocols on the
mouse ear swelling test (MEST)… also evident in the pathological slides of the ear tissues. The …

… delivery also requires the proper expansion and transduction of primary cell populations. For
instance, adenovectors … AAV-inner ear (AAV-ie) for gene therapy in a mouse inner ear [298]…

… Systematic delivery of OVs offers several advantages over IT … the collagen content of tumor
tissue. Furthermore, IT injection … to the control Ad vector in the mouse 4 T1 cell line and A549 …

… successfully transform into inner ear cells and tissues in vitro … Atoh1-expressing adenovector
to a mouse model with … Possible targets in the inner ear for the delivery of vectors for …

… expression in the shaker-1 mouse, an animal model of USH1B… gene delivery to an animal
retina using an adenovirus vector. (… known to express in tissues within the inner ear and retina, …